New Paper: Alternate sessions of transcranial direct current stimulation (tDCS) reduce chronic pain in women affected by chikungunya. A randomized clinical trial

New publication in Brain Stimulation

Alternate sessions of transcranial direct current stimulation (tDCS) reduce chronic pain in women affected by chikungunya. A randomized clinical trial

Clécio Gabriel de Souza, Rodrigo Pegado, Jardson Fausto da Costa, Edgard Morya, Abrahão Baptista, Gozde Unal, Marom Bikson, & Alexandre Hideki Okano

Brain Stimulation | (2021) | https://doi.org/10.1016/j.brs.2021.02.015

Download PDF

Abstract:

Context

Thousands of people worldwide have been infected by the chikungunya virus (CHIKV), and the persistence of joint pain symptoms has been considered the main problem. The mechanisms of neuropathic pain include cortical areas. Neuromodulation techniques such as transcranial direct current stimulation (tDCS) act on brain areas involved in the processing of chronic pain. It was previously demonstrated that tDCS for five consecutive days significantly reduced pain in the chronic phase of chikungunya (CHIK).

Objective

To analyze the effect of alternate tDCS sessions on pain and functional capacity in individuals affected by CHIK.

Methods

In a randomized clinical trial, 58 women in the chronic phase of CHIK were divided into two groups: active tDCS (M1-S0, 2mA, 20 minutes) and sham. The Visual Analogue Scale (VAS) and Brief Pain Inventory (BPI) were used to assess pain, while the Health Assessment Questionnaire (HAQ) assessed functional capacity. These scales were used before and after six sessions of tDCS in nonconsecutive days on the primary motor cortex, and at follow-up consultation 7 and 15 days after the last session. A repeated measures mixed-model ANOVA was used for comparison between groups (significant p-values < 0.05).

Results

A significant pain reduction (Z[3, 171] = 14.303; p < 0.0001) was observed in the tDCS group compared to the sham group; no significant difference in functional capacity was observed (Z[1.57] = 2.797; p = 0.1).

Conclusion

Our results suggest that six nonconsecutive sessions of active tDCS on M1 reduce pain in chronic CHIKV arthralgia.