Bikson speaks at Cleveland FES Center, Dec 5 (live Webinar)

Update watch talk video here

Prof. Marom Bikson speaks at the Cleveland FES Center NEURAL PROTHESIS LIVE WEBINAR on Dec 5, 2019 at 3:00 PM. Live Stream at: http://fescenter.org/news-events/webinar-series/

Download presentation slides

Title: Neuromodulation though BBB stimulation or Heating: New Mechanisms of DBS, SCS, and tDCS

Abstract: This seminar explores when direct heating of tissue or direct stimulation of endothelial cells of the blood-brain barrier (BBB) is the the mechanisms of action in neuromodulation. Specific approaches considered are Spinal Cord Stimulation (SCS), kHz-frequency SCS, Deep Brain Stimulation (DBS), kHz-frequency DBS, and transcranial Direct Current Stimulation.

Results are based on computational modeling (including bio-heat FEM), phantoms, and animal models (including in vivo imaging, brain slices, and in vitro endothelial monolayers). Moderate (~1 C) non-injurious heating of tissue results from higher-power waveforms with implanted electrodes (kHZ SCS, high-density SCS, kHZ DBS). Especially when sustained over long periods, moderate heating will modulate brain function. Immediate and lasting non-injurious changes in BBB permeability can occur during SCS, DBS, and tDCS. Even small changes in BBB function can have profound effects on brain function. These results are shown to derive from well established physical principles such as joule heat and electroosmosis.

In some cases heating or BBB mechanisms operate parallel to traditional nervous tissue stimulation, and in others applications they may underpin responsiveness and so govern secondary neuronal changes.

DownloadL Flier