Neuroimage. 2017 May 31;157:69-80. doi: 10.1016/j.neuroimage.2017.05.059.
Optimal use of EEG recordings to target active brain areas with transcranial electrical stimulation.
Dmochowski JP, Koessler L, Norcia AM, Bikson M, Parra LC.
Full paper: OptimalUseEEG_2016
Abstract: To demonstrate causal relationships between brain and behavior, investigators would like to guide brain stimulation using measurements of neural activity. Particularly promising in this context are electroencephalography (EEG) and transcranial electrical stimulation (TES), as they are linked by a reciprocity principle which, despite being known for decades, has not led to a formalism for relating EEG recordings to optimal stimulation parameters. Here we derive a closed-form expression for the TES configuration that optimally stimulates (i.e., targets) the sources of recorded EEG, without making assumptions about source location or distribution. We also derive a duality between TES targeting and EEG source localization, and demonstrate that in cases where source localization fails, so does the proposed targeting. Numerical simulations with multiple head models confirm these theoretical predictions and quantify the achieved stimulation in terms of focality and intensity. We show that constraining the stimulation currents automatically selects optimal montages that involve only a few (4-7) electrodes, with only incremental loss in performance when targeting focal activations. The proposed technique allows brain scientists and clinicians to rationally target the sources of observed EEG and thus overcomes a major obstacle to the realization of individualized or closed-loop brain stimulation.
“Noninvasive Neuromodulation Goes Deep” Jacek Dmochowski and Marom Bikson, Cell. http://dx.doi.org/10.1016/j.cell.2017.05.017
Modulating deep regions of the brain with noninvasive technology has challenged researchers for decades. In a new study, Grossman et al. leverage the emergence of a slowly oscillating ‘‘beat’’ from intersecting high-frequency electric fields to stimulate deep brain regions, opening a frontier in the biophysics and technology of brain stimulation. Download PDF: FullPaper
Prof. Marom Bikson gives two invited talk at the International Neuromodulation Society meeting in Edinburgh May 27-30. Conference details link
May 27, 2017 “Toward Markers of Target Engagement in tDCS” in the pre-conference on Non-Invasive Brain Stimulation.
Download slides talk 1: Bikson_INS_2017finalA.compressed
May 29, 2017 “Mechanistic Questions around High-Rate Stimulation and Overview of Methods for Reliable Electrophysiological Recording During High-Rate (10k) Stimulation” in breakout session Mechanisms and Models of High-rate Electrical Stimulation (chaired by Dr. Bikson)
Download slides talk 2:29-1430-BIKSON-BREAKOUT_Fd.compressed
The Science of Consciousness June 5-10, 2017 La Jolla, California
‘The Science of Consciousness’ (‘TSC’) is an interdisciplinary conference on all aspects of the nature of conscious experience, awareness, feelings and existence. How does the brain produce consciousness? Is consciousness intrinsic to the universe, or an epiphenomenal illusion? How can consciousness causally affect brain processes? What are the best empirical theories? Do we have free will? How did life and consciousness originate and evolve? What are the origins of moral and aesthetic values? How can we improve mental, physical and cognitive function? Can consciousness persist after bodily death, e.g. through ‘uploading’ to machines, or via mental processes tied to the natural world?
For registration, hotel and other information see: http://www.consciousness.arizona.edu
Marom Bikson, CCNY/CUNY, ‘Non-Invasive Brain Stimulation Devices to Change Thought and Behavior’
June 6: PL4 2:00 to 4:10 pm Non-Invasive Brain Stimulation
Marom Bikson speaks on the future of tDCS in the home for Pain treatment and other indications at the American Pain Society meeting. May 19, 2017 (conference page)
Slides here: Bikson_tDCShome_2017
The CCNY Neural Engineering group is excited for two important papers on the mechanisms of tDCS published in the same issue of Brain Stimulation journal.
Direct Current Stimulation Modulates LTP and LTD: Activity Dependence and Dendritic Effects.
Kronberg G, Bridi M, Abel T, Bikson M, Parra LC.
Brain Stimul. 2017 Jan – Feb;10(1):51-58. doi: 10.1016/j.brs.2016.10.001. Epub 2016 Oct 5. PMID: 28104085
Download PDF: Kronberg_DCS
Direct Current Stimulation Alters Neuronal Input/Output Function.
Lafon B, Rahman A, Bikson M, Parra LC.
Brain Stimul. 2017 Jan – Feb;10(1):36-45. doi: 10.1016/j.brs.2016.08.014. Epub 2016 Sep 1.PMID: 27717601
Download PDF: Lafon_DCS
The SF Giants Are Zapping Their Brains With Electricity. Will It Help? MAY 8, 2017
“People like to say that electricity is the currency of the brain and that in many ways the brain is a circuit,” says Marom Bikson, a professor of biomedical engineering at City College of New York. “So when we apply electricity to the brain, we interact with that circuit, and we can change how that circuit works.”
Dr. Marom Bikson lecture on Major mechanistic questions and technology opportunities in Spinal Cord and Deep Brain Stimulation
Department of Neurosurgery, Mt Sinai Health System, May 3, 2017. 8 AM. Annenberg Building, 1468 Madison Avenue, 5th floor seminar room.
Jackson MP, Truong D, Brownlow ML, Wagner JA, McKinley RA, Bikson M, Jankord R. Safety parameter considerations of anodal transcranial Direct Current Stimulation in rats. Brain, Behavior, and Immunity 2017 pii: S0889-1591(17)30110-1. doi: 10.1016/j.bbi.2017.04.008 Jankord_Safety_tDCS_2017
Nitsche M. Bikson M. Extending the parameter range for tDCS: Safety and tolerability of 4 mA stimulation. Brain Stimulation. Editorial, Volume 10, Issue 3, Pages 541–542, 2017 Nitche_Bikson_BrainStim_2017
And don’t forget our seminal 2016 safety review here
April 7, 2017. 11:00 am to 12:30 pm, 333 Curry Student Center, Northeastern University, Boston
“Translational Neural Engineering: Accelerated medical device design for treatment of neuro-psychiatric disorders and brain injury”
The design and clinical deployment of new medical devices on an accelerated time scale (as little at 6 months) requires an interdisciplinary team and skill set spanning basic science, biomedical engineering, regulatory, and clinical trials. This talk uses a series of case-studies to diagram a process for rapid translational medical device design, with a focus on non-invasive electrical stimulation technology. This generalizable medical design process is translational because basic science stages are already informed by regulatory and clinical challenges, while clinical trials are designed around engineering features and limitations.